陈士林,首席研究员,现任中国中医科学院中药研究所所长,世界卫生组织传统医学合中心主任;国际欧亚科学院院士; CGCM(中药全球化联盟)副主席。曾任香港理工大学访问教授,并在英国皇家植物园丘园接受专业培训、哈佛医学院Mclean医院做访问学者等。现兼任“濒危药材繁育国家工程实验室”主任、中国药学会中药与天然药物专业委员会主任委员、美国药典传统中药咨询组顾问等。
现为教育部长江学者创新团队负责人,并担任Pharmaceutical Crops共同主编,CHM、《药学学报》副主编,PLOS ONE等十余种国际国内学术刊物的编委;在国际上创建了基于ITS2的中草药DNA条形码鉴定方法体系,完成专著《中药DNA条形码分子鉴定》、《中国药典中药材DNA条形码标准序列》;通过全基因组解析提出灵芝为首个中药基原药用模式真菌,论文在《自然 通讯》发表,被Nature China 选为中国最佳研究亮点推介。完成了260 余种中药材产地生态适宜性数值区划,编著《中国药材产地生态适宜性区划》;获得国家科技进步二等奖2 项;发表论文300余篇,其中SCI 180 余篇,包括平均IF>10的国际著名期刊 Nat Commun、Biotech Adv、PNAS、Nat Prod Rep、Biol Rev 等, 论文被引用7100余次。
近期主要论文:
1. Shilin Chen*, J Xu, C Liu, Y Zhu, D R.Nelson, S Zhou, C Li, L Wang, X Guo, Y Sun, H Luo, Y Li, J Song, B Henrissat, A Levasseur, J Qian, J Li, X Luo, L Shi, L He, L Xiang, X Xu, Y Niu, Q Li, Mira V.Han, H Yan, J Zhang, H Chen, A Lv, Z Wang, M Liu, David C. Schwartz3& C Sun* Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Commun 2012
2. Pang XH, Song JY, Zhu YJ, Xu HX, Huang LF, Chen SL*. Applying plant DNA barcodes for Rosaceae species identification. Cladistics 2011
3. China Plant BOL Group1, Comparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants. PNAS(2011)
4. Qiushi Li, Ying Li, Jingyuan Song, Haibin Xu, Jiang Xu, Yingjie Zhu, Xiwen Li, Huanhuan Gao, Linlin Dong, Jun Qian, Chao Sun, Shilin Chen* High-accuracy de novo assembly and SNP detection of chloroplast genomes using a SMRT circular consensus. NEW PHYTOL (2014)
5. Shilin Chen*, Xiaohui Pang, Jingyuan Song, Linchun Shi, Hui Yao, Jianping Han, Christine Leon. A renaissance in herbal medicine identification From morphology to DNA. JAB (2014)
6. Y Zhu, H Luo, X Zhang, J Song, C Sun, A Ji,J Xu Shilin Chen* Abundant and Selective RNA Editing Events in the Medicinal Mushroom Ganoderma lucidum. Genetics 2014
7. X Li, Y Yang, R J. Henry, M Rossetto, Y Wang* and S Chen* Plant DNA barcoding: from gene to genome. Biol Rev (2014)
8. L Xiang, J Song, T Xin, Y Zhu, L Shi, X Xu, X Pang, H Yao, W Li and Shilin Chen* DNA barcoding the commercial Chinese caterpillar fungus. FEMS Microbiology Letters 2013
9. C Li, Y Zhu, X Guo, C Sun, H Luo, J Song, Y Li, L Wang, J Qian, S Chen*. Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng C.A.Meyer. BMC Genomics (2013)
10. Xu J; Xu Z; Zhu Y; Luo H; Qian J; Ji A; Hu Y; Sun W; Wang B; Song J; Sun C Chen ShiLin; Identification and Evaluation of Reference Genes for qRT-PCR Normalization in Ganoderma lucidum. Current microbiology 2014
11. Dong,L; Yao,H; Li,Q; Song,J; Li,Y; Luo,H; Chen,S Investigation and integrated molecular diagnosis of root-knot nematodes in Panax notoginseng root in the field European Journal of Plant Pathology (2013)
12. L Xiang, Y Li, Y Zhu, H Luo, C Li, X Xu, C Sun, J Song, L Shi, L He, W Sun, Shilin Chen*. Transcriptome analysis of the Ophiocordyceps sinensis fruiting body reveals putative genes involved in fruiting body development and cordycepin biosynthesis. Genomics (2014)
13. Sun C, Li Y, Wu Q, Luo HM, Sun YZ, Song JY, Lui E, Chen SL*. De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. BMC Genomics (2010)
14. Shilin Chen*, Yao H, Han JP, Liu C, Song JY, Shi LC, Zhu YJ, Ma XY, Gao T, Pang XH, Luo K, Li Y, Li XW, Jia XC, Lin YL, Leon C.Validation of the ITS2 Region as a Novel DNA Barcode for Identifying Medicinal Plant Species. PLoS ONE (2010)
15. Luo H, Li Y, Sun C, Wu Q, Song J, Sun Y, Steinmetz A, Shilin Chen*. Co mparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. BMC Plant Biol (2010)
16. S Chen*, H. Luo, Y. Li, Y. Sun, Q. Wu, Y. Niu, J. Song, A. Lv, Y. Zhu, C. Sun, A.Steinmetz & Z. Qian 454 EST analysis detects genes putatively involved in ginsenoside biosynthesis in Panax ginseng. Plant Cell Rep (2011)
17. J Qian, J Song, H Gao, Y Zhu, J Xu, X Pang, H Yao, C Sun, X Li, C Li, J Liu, H Xu, Shilin Chen, The Complete Chloroplast Genome Sequence of the Medicinal Plant Salvia miltiorrhiza PLoS ONE (2013)
18. Y Sun, H Luo, Y Li, C Sun, J Song, Y Niu, Y Zhu, L Dong, A Lv, E Tramontano, Shilin Chen* Pyrosequencing of the Camptotheca acuminata transcriptome Reveals Putative Genes Involved in Camptothecin Biosynthesis and Transport. BMC Genomics (2011)
19 黄林芳, 郑司浩, 武拉斌, 降雪, 陈士林* 基于化学成分及分子特征中药材肉苁蓉生态型研究 中国科学C 2014,第44卷 第2期
20 孙超, 胡鸢雷, 徐江, 罗红梅, 李春芳, 宋经元, 郭红卫, 陈士林* 灵芝: 一种研究天然药物合成的模式真菌 中国科学C 2013年 43(6):
21 陈士林*, 庞晓慧, 罗焜, 姚辉, 韩建萍, 宋经元 生物资源的DNA条形码技术 生命科学 2013 (25):4
22 徐江, 孙超, 徐志超, 季爱加, 胡鸢雷, 孙伟, 王丽芝, 汪波, 杨培, 张鑫, 宋经元, 陈士林* 药用模式生物研究策略 科学通报 (2014)